Pharmaceuticals have primarily consisted of simple, fast-acting chemical compounds that are dispensed orally or as injectables. Formulations that control the rate and period of drug delivery  and target specific areas of the body for treatment have become increasingly common and complex. Direct drug Delivery Systems are where drug is released directly to the diseased part. Drug development platforms use a detailed examination of bioactivities, including morphological change, cell death and gene expression patterns at the cell or whole organism level, and a toxicity evaluation using cardiomyocyte cells differentiated from induced pluripotent stem cells.

Research model cell from a human embryonic stem (ES) cell that will make it possible to more accurately determine at an earlier stage whether a new drug can advance to the clinical test stage. In addition, development of a drug discovery support system that allows quantitative assessment of effects, toxicity and adverse reactions associated with drugs will also be carried out through the integration of model cells and various device technologies.

he introduction of a new drug discovery process based on genome information was expected to bring efficiency to drug development and, as a result, reduce the time for market introduction and the cost of new drugs.

Number of new drugs introduced in the market is decreasing year by year in spite of a higher level of R&D investment, creating a gap in genome-based drug discovery. Development of drug discovery support technology that makes the development process more efficient.

Gene functions and the safety and effect of newly developed drugs have been identified and evaluated on mice and rabbits, and human cell lines. However, since animal cells and cultured human cells differ in character from human in vivo cells, it is difficult to accurately predict reactions that actually will occur in human in vivo cells. In fact, there are a number of cases where development was abandoned during clinical testing because of safety-related issues or effects. Therefore, it is necessary to develop an evaluation system using cells that are similar in
nature to actual human in vivo cells.

Research model cell from a human embryonic stem (ES) cell that will make it possible to more accurately determine at an earlier stage whether a new drug can advance to the    clinical test
stage. In addition, development of a drug discovery support system that allows quantitative assessment of effects, toxicity and adverse reactions associated with drugs are carried out through the integration of model cells and various device technologies.

Cancer can happen in lungs and pancreas and Direct Drug Delivery Systems can deliver the Drug directly to the effected areas. Conventional treatment techniques such as surgical procedures, chemotherapy and radiotherapy, have disadvantages, including severe side effects resulting from the spread of drugs throughout the body and damage to normal cells due to exposure to x-rays and steroids. In order to eliminate such side effects technology that delivers drugs only to cancer cells with pinpoint accuracy. Medicinal effects are exerted selectively only in the affected area by Direct Drug Delivery Systems.

Photodynamic therapy system that integrates innovative drug delivery systems and optical fiber technology Through effective integration of the development of drug delivery system technology that selectively delivers drugs with medicinal effects that are expressed through the stimulation of the body using safe light energy (photo-sensitizers) to cancer cells, and development of optical fiber and light irradiation devices that can deliver light to all tumors within the body in an efficient and minimally invasive manner, a therapeutic system that can effect a permanent cure for intractable cancers without inflicting damage on normal tissue will be developed. Preclinical tests of the therapeutic system will also be carried out on epithelial cancers such as those in the bladder and esophagus to verify its effectiveness and safety. Systems utilizing interaction of electromagnetic pulses or ultrasonic radiation with nano- and micro-particles for enhancement of drug delivery in solid tumors. The particles can be attached to antibodies directed against antigens in tumor vasculature and selectively delivered to tumor blood vessel walls. Cavitation induced by ultrasonic waves or local heating of the particles by pulsed electromagnetic radiation results in perforation of tumor blood vessels, microconvection in the interstitium, and perforation of cancer cell membrane, and therefore, provides enhanced delivery of macromolecular therapeutic agents from blood into cancer cells with minimal thermal and mechanical damage to normal tissues.

Multiphoton microscopy is used in life-science research. However, it is crucial to point out that the growth of multiphoton imaging has been boosted by the ability to produce living samples via genetic manipulation, in which only specific and selected features fluoresce. Multiphoton microscopy is now being applied in all major areas of biological research ranging from stem cells to cancer and heart studies. Initially, imaging was undertaken using a colliding pulse dye laser – not the type of instrument to be used lightly in a biology laboratory. The development of reliable femto-second near-infrared sources has enabled life scientists to concentrate on the biology rather than having to become laser experts. The change from water-cooled argon lasers to compact diode-pumped, frequency-doubled solid-state pump lasers has also contributed to the revolution in imaging.

Advanced Platform is provided by Recom Systems Limited where all the information can be stored and searched using Artificial Intelligence tools. Online Training System is part of this Platform which is also integrated with Knowledge Discovery Platform. Data Mining Tools help to segregate useless data and useful data from Research trials. Send us an email for further enquiries sales@recomsys.net