Biotechnology

Conventional cancer treatment techniques, such as surgical procedures, chemotherapy and radiotherapy, have disadvantages, including severe side effects resulting from the spread of drugs throughout the body and damage to normal cells due to exposure to x-rays. Direct Drug Delivery to Diseased part is implemented using Photodynamic therapy system that integrates innovative drug delivery systems and optical fiber technology.
Through effective integration of the of drug delivery system technology that selectively delivers drugs with medicinal effects that are expressed through the stimulation of the body using photo-sensitizers to cancer cells, optical fiber and light irradiation devices that can deliver light to all tumors within the body in an efficient and minimally invasive manner, a therapeutic system that can effect a permanent cure for intractable cancers without inflicting damage on normal tissue.

Patients with severe cardiac failure due to ischemic heart disease will further increase in the future. Regenerative Medicine using cell sheet engineering can be used. This supports patients with severe cardiac failure to return to everyday life and to help them significantly improve their quality of life more quickly. This is to establish technology for producing regenerated myocardial tissue (bio-myocardium) by further advancing the cell sheets. Such a bio-myocardium, which is a stack of cell sheets, will have vascular networks capable of supplying oxygen and nutrients inside the structure and have sufficient strength and functions to repair myocardium defects.

Recom Systems can take up new Research Projects using Artificial Intelligence and Genetic Programming.

Biotechnology combines disciplines like genetics, molecular biology, biochemistry, embryology and cell biology, which are in turn linked to practical disciplines like chemical engineering, information technology, and bio-robotics. Patho-biotechnology describes the exploitation of pathogens or pathogen derived compounds for beneficial effect In order to realize a healthy, vigorous and safe life, it is necessary to develop basic health and medical technology as well as
technology that makes use of biological functions.

Analysis Technology for Gene Functions with Cell Arrays

Next-generation technology for drug treatment target discovery depends on the elucidation of intracellular signaling networks, which should be modeled from large-scale molecular and cellular response data. Cell-based array technologies are being used for highly parallel real-time monitoring of cellular and molecular response functions to clarify signaling networks by using various human cells. This leads to realization of network-based determination of drug treatment targets. Genetic Expression Programming is used to classify data leading to new drug discovery for Cancer.

Bacterial cell expression technology (BCE) is an enabling technology used to discover and screen, as well as develop and manufacture, recombinant antibodies for commercial purposes. BCE is also a key technology used in multiple systems for high-throughput screening of antibody domains. Expression of antibodies by phage display technology, for example, depends on the expression and secretion of antibody domains from bacteria as properly folded, functional proteins.

Marine Life so far is relatively unmodified area and lot can be done to modify marine life to support the Global Food Requirement. Bio-technology can help in great way to achieve this objective. Marine biotechnology is about the discovery and development of marine resources (like marine organisms) into a wide range of new products, e.g. food, food additives, healthcare, cosmetics, pharmaceuticals and medical applications. These organisms have been in the spotlight owing to their unique features, which part them from the rest of the terrestrial biodiversity. These organisms have been found to possess characteristics like alkalinity tolerance, thermo tolerance, baro tolerance and the ability to use unusual molecules. These attributes make marine organisms a useful resource for use in different industries, bioremediation and agriculture. Marine biotechnology is gearing up globally too. About 10,000 compounds are known from marine sources. Already many compounds are in the final testing stage for antiviral, anticancer, antihypertensive and anti parkinsonian activity. Many industrial enzymes could be obtained from marine organisms. In fact they can be much superior compared to those from terrestrial source. Vibrio alginolyticus, a marine bacterium produces a detergent resistant protease that can find application in detergent industries. What is interesting is since the bacterium lives in high salt concentration, the enzyme will act in low water activity situation such as those encountered in industries where organic solvents are used. For the same reason many halophilic bacteria can work better in bioremediation and effluent treatment.

Proteins work together to form networks. By knowing the specific networks of the proteins related to various diseases,it will be possible to elucidate the development mechanism of diseases such as cancer and other lifestyle-related diseases and identify new drug discovery targets.
Drug candidates can be narrowed down through analysis of the interaction between target proteins by making maximum use of extensive full-length cDNA resources and protein interaction analysis.  Such physiologically active substances can then serve as drug development platforms after a detailed examination of bioactivities, including morphological change, cell death and gene expression patterns at the cell or whole organism level, and a toxicity evaluation using cardiomyocyte cells differentiated from induced pluripotent stem cells (iPSCs).

Proteins, including protein complexes, considered to be important for industry-related post-genome research such as drug discovery and other uses. The targets of the development are antigen production technology that can systematically create antibodies having a high specificity, technology to enhance antigen presentation and avoid immunological tolerance, and technology to efficiently separate and purify antibodies.

Intelligent Surgical Instruments Using High level Programming and Robotics technology Application areas are neurosurgery,thoracic surgery and digestive surgery. These instrument require real-time sensing technology to detect normal tissue and lesions; information technology for the integration of data from real-time sensing, endoscopic and other pre- and intra-operative images; and dexterous manipulation technology.

Regenerative Medicine is a new technology would make it possible to replace some parts of body organs and functions that have been disabled by sickness, accident or disease. In order to realize an early introduction of regenerative medicine for practical use, it is necessary to ensure its safety and effectiveness. At the same time, development of related technologies, including devices to enable efficient measurement and evaluation of various characteristics of cells to be used, is needed. In particular, a series of evaluation processes should be established to enable efficient checking and verification of the adequacy of cells for transplantation and any risk of infections throughout the process of cell harvesting from humans, cultivation, differentiation, and cultivation together with biomaterials as scaffolding materials.